CD49d-Biotin, human
货号：
130-108-256 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-108-256 |
| 描述 | Clone REA545 recognizes the human CD49d antigen, which belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD49d, also known as the α4 integrin chain or VLA-4α chain, is a cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with β7 integrin, the resulting α4β7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin to facilitate the rolling of leukocytes along vascular epithelium. In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling. CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils.Additional information: Clone REA545 displays negligible binding to Fc receptors. |
| 别名 | ITGA4, IA4 |
| 克隆号 | REA545 |
| 同种亚型 | recombinant human IgG1 |
