CD366 (TIM-3)-Biotin, human 30 tests
货号：
130-109-762 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-109-762 |
| 描述 | Clone REA635 recognizes the human CD366 antigen, a single-pass type I membrane protein, which is also known as T cell immunoglobulin and mucin domain containing protein-3 (TIM-3) or Hepatitis A virus cellular receptor 2 (HAVcr-2). CD366 is expressed on activated T cells, especially Tʜ1 cells, monocytes, macrophages, and dendritic cells. It is an activation-induced inhibitory molecule involved in tolerance and shown to induce T cell exhaustion in chronic viral infection and cancers. CD366 has been proposed to inhibit Tʜ1-mediated immune responses and regulates Tʜ1 and Tʜ17 cytokine secretion. The interaction of CD366 and its ligand galectin-9 induces apoptosis of Tʜ1 cells.Additional information: Clone REA635 displays negligible binding to Fc receptors. |
| 别名 | HAVcr-2, TIMD-3 |
| 克隆号 | REA635 |
| 同种亚型 | recombinant human IgG1 |
