Anti-CLA-FITC, human 30 tests
货号：
130-099-614 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-099-614 |
| 描述 | The Anti-CLA antibody recognizes the cutaneous lymphocyte-associated antigen (CLA), a specialized glycoform of P-selectin glycoprotein ligand-1 (PSGL-1). It serves as a ligand for selectins, including CD62E (ELAM-1) and CD62L (LECAM-1). CLA is a unique skin-homing receptor and is predominantly found on a minor subset of human T cells that infiltrate the skin. This post-translational modification of PSGL-1 is thought to serve as a mechanism to regulate tissue-specific homing of CD4+ and CD8+ memory/effector T cells from peripheral blood to the skin, which plays an essential role during many inflammatory and certain malignant skin diseases.In peripheral blood, CLA is not only found on skin-homing
memory/effector T cells, but is also found to be expressed on memory/effector B cells, NK cells, blood dendritic cells, and on monocytes. CLA is furthermore found on Langerhans cells in the skin. |
| 别名 | SELPLG, CD162, PSGL-1, PSGL1 |
| 克隆号 | HECA-452 |
| 同种亚型 | rat IgMκ |
