CD94-Biotin, human 30 tests
货号：
130-098-967 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-098-967 |
| 描述 | The clone REA113 recognizes CD94, an approximately 45 kDa, single-pass, type II transmembrane protein, which belongs to C-type lectin superfamily. CD94 associates covalently with NKG2 family members and forms disulfide bonded heterodimers. CD94-NKG2 receptors bind HLA-E, the non-classical MHC class Ib molecule. Depending on the associated NKG2 member, CD94-NKG2 heterodimer transmits either activating or inhibitory signal. For, e.g, via immunoreceptor tyrosine based-inhibitory motifs (ITIMs) containing NKG2A, CD94-NKG2A heterodimers inhibit NK cell cytotoxicity. Besides NK cells, expression of CD94-NKG2 heterodimers is also shown on NK-T cells and a small percentage of CD8 cells in mice, where the crosslinking of CD94-NKG2 was shown to reduce the level of spontaneous apoptosis. Additional information: Clone REA113 displays negligible binding to Fc receptors. |
| 别名 | KLRD1, Kp43 |
| 克隆号 | REA113 |
| 同种亚型 | recombinant human IgG1 |
