CD48-Biotin, human 30 tests
货号：
130-106-515 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-106-515 |
| 描述 | Clone REA426 recognizes the human CD48 antigen, a glycosyl-phosphatidyl-inositol (GPI)-anchored cell-surface protein of the CD2 family of molecules, which is also known as B-lymphocyte activation marker BLAST-1, BCM1, MEM-102, or SLAM family member 2 (SLAMF2). CD48 is expressed on various hematopoietic cells and its expression is regulated by viral and bacterial products and immune-associated proteins. CD48 binds CD2 and other molecules, yet its high-affinity ligand in both mouse and human systems is CD244 (2B4). Despite its lack of an intracellular domain, stimulation of CD48 induces rearrangement of signaling factors in lipid rafts, Lck-kinase activity, and tyrosine phosphorylation. As an adhesion and co-stimulatory molecule, CD48 induces numerous effects in B and T lymphocytes, natural killer cells, mast cells, and eosinophils. Some of these depend upon cell-cell interactions via CD244-CD48 binding. Additional information: Clone REA426 displays negligible binding to Fc receptors. |
| 别名 | Blast-1, BCM1, BLAST, MEM-102, SLAMF2, hCD48, mCD48, Blast-1, TCT.1 |
| 克隆号 | REA426 |
| 同种亚型 | recombinant human IgG1 |
