CD269 (BCMA)-Biotin, human 30 tests
货号：
130-104-549 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-104-549 |
| 描述 | Clone REA315 recognizes the human CD269 antigen, a Single-pass type III membrane protein which is also known as B cell maturation antigen (BCMA). CD269 is a member of the TNF-receptor superfamily that is preferentially expressed in mature B lymphocytes. It is the receptor for CD256 (TNFSF13, APRIL) and CD257 (TNFSF13B, BLyS, BAFF). CD269 promotes B cell survival and plays a role in the regulation of humoral immunity. Binding of CD269 to CD257 blocks the binding of CD257 to its receptor on the plasma membrane and inhibits CD257-triggered B lymphocyte costimulation. Overexpression of CD269 activates NF-κ-B and JNK, and this activation is potentiated by CD257.Additional information: Clone REA315 displays negligible binding to Fc receptors. |
| 别名 | TNFRSF17, Bcm, BCMA, Tnfrsf13a |
| 克隆号 | REA315 |
| 同种亚型 | recombinant human IgG1 |
