CD267 (TACI)-Biotin, human 30 tests
货号：
130-100-661 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-100-661 |
| 描述 | Clone 1A1 recognizes human CD267, a 32 kDa type III transmembrane protein belonging to the TNF receptor superfamily. CD267 as receptor binds to BAFF and APRIL and plays an important role in the stimulation of B- and T-cell function and in the regulation of humoral immunity. CD267 expression is found in CD27+ memory B cells, tonsillar and bone marrow plasma cells, in a subpopulation of activated CD27-, non GC cells and in a small subset of naïve blood and tonsil B cells. CD267 is also expressed on many lymphomas such as multiple myeloma and Hodgkin and non-Hodgkin lymphomas. Mutations in CD267 are often associated with common variable immunodeficiency in humans. Signaling via CD267 leads to activation of the transcription factors NFAT, AP1, and NF-kappa-B. |
| 别名 | TNFRSF13B, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B |
| 克隆号 | 1A1 |
| 同种亚型 | rat IgG2aκ |
