CD201 (EPCR)-Biotin, human 30 tests
货号：
130-105-296 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-105-296 |
| 描述 | Clone REA337 recognizes the human CD201 antigen, a single-pass type I membrane protein which is also known as Endothelial protein C receptor (EPCR). CD201 is strongly expressed in the endothelial cells of arteries and veins in heart and lung, and less intensely in capillaries in the lung and skin. It is also expressed on a subset of neutrophils, monocytes and several tumor cells. The major role of CD201 is anticoagulation. CD201 binds to protein C with high affinity and augments the activation of protein C by the thrombin-thrombomodulin complex. Another important functional aspect of CD201 is its role in many pathophysiologic processes, such as inflammation responses to infection, trauma, hematopoiesis, and autoimmune response. Mutations in the CD201 gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.Additional information: Clone REA337 displays negligible binding to Fc receptors. |
| 别名 | Procr, CCCA, CCD41, EPCR |
| 克隆号 | REA337 |
| 同种亚型 | recombinant human IgG1 |
