CD170 (Siglec-5)-FITC, human 30 tests
货号：
130-101-801 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-101-801 |
| 描述 | Clone 1A5 recognizes the CD170 antigen, a single pass transmembrane protein member of the immunoglobulin superfamily and is also known as sialic acid-binding Ig-like lectin 5 (Siglec-5). CD170 is expressed on neutrophils, monocytes, dendritic cells, and subsets of tissue macrophages. It contains two tyrosine-based motifs in its cytoplasmic tail implicating signaling functions and forms a 140 kDa dimer on the cell surface. Tyrosine phosphorylation of CD170 leads to recruitment of the tyrosine phosphatases SHP-1 and SHP-2, which in turn efficiently inhibits FcεRI-mediated calcium fluxing and serotonin release. CD170 binds α 2-3- and α 2-6-linked sialic acid as well as glycophorin A, and is involved in cell adhesion. |
| 别名 | CD33L2, OB-BP2, OBBP2, Siglec-5 |
| 克隆号 | 1A5 |
| 同种亚型 | mouse IgG1κ |
