CD16 (REA423)-Biotin, human 30 tests
货号：
130-106-758 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-106-758 |
| 描述 | Clone REA423 recognizes the human CD16 antigen, a single-pass type I membrane protein which is also known as low affinity immunoglobulin gamma Fc region receptor III (FcRIII). CD16 is a 50–80 kDa glycoprotein that is expressed in two different isoforms. The transmembrane form is found on human NK cells, macrophages, and mast cells, while the glycosylphosphatidylinositol (GPI)-linked form is present on neutrophils. The human CD16 antigen is a low-affinity receptor for aggregated IgG. The transmembrane form plays a role in signal transduction, NK cell activation, and antibody-dependent cellular cytotoxicity. Clone REA423 recognizes both the extracellular domain of the transmembrane form as well as the GPI-linked form of the human CD16 antigen. CD16 is expressed on the majority of rhesus monkey NK cells and on a subset of monocytes but not on granulocytes. Additional information: Clone REA423 displays negligible binding to Fc receptors. |
| 别名 | FCGR3A, FCGR3B, FcR-10, IGFR3, IMD20, FcRIII |
| 克隆号 | REA423 |
| 同种亚型 | recombinant human IgG1 |
