CD120a (TNF-R1)-Biotin, human 30 tests
货号：
130-106-358 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-106-358 |
| 描述 | Clone REA252 recognizes the extracellular part of the membrane-bound and soluble form of the CD120a antigen, a 55 kDa type I transmembrane glycoprotein also known as tumor necrosis factor receptor type I (TNF-RI) or p55. CD120a belongs to the TNF receptor superfamily and is mainly expressed by monocytes, macrophages, and neutrophils. It is also expressed by a variety of cell lines, tumor cells, and normal cell types including T cells, endothelial cells, hepatocytes, chondrocytes, and fibroblasts. Binding of TNF-α to its main receptor CD120a triggers signaling which is extremely complex, leading to both cell death and survival signals. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of human diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Additional information: Clone REA252 displays negligible binding to Fc receptors. |
| 别名 | TNFRSF1A, FPF, MS5, TBP1, p55, p60, TNF-R1 |
| 克隆号 | REA252 |
| 同种亚型 | recombinant human IgG1 |
