Anti-Siglec-5/Sig-14-Biotin, h 30 tests
货号：
130-106-170 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-106-170 |
| 描述 | Clone REA393 recognizes the human siglec-5 and siglec-14 antigens, which are both single pass transmembrane protein members of the immunoglobulin superfamily. Siglec-5 is also known as CD170. Siglec-5 has four extracellular Ig-like domains and a cytosolic inhibitory motif. Siglec-14 was discovered with three Ig-like domains and has almost complete sequence identity with siglec-5 at the first two Ig-like domains, shows a glycan binding preference similar to that of siglec-5, and associates with the activating adapter protein DAP12. Siglec-5 is expressed on granulocytes and monocytes as well as on plasmacytoid dendritic cells, monocyte-derived dendritic cells, and macrophages. It is potentially involved in the negative regulation of innate immune responses, and also suggested to be a useful diagnostic and therapeutic marker for acute myelogenous leukemia. Siglec-14 is expressed on granulocytes and B cells. Some individuals lack the expression of siglec-14, while they all express siglec-5. Additional information: Clone REA393 displays negligible binding to Fc receptors. |
| 别名 | CD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14 |
| 克隆号 | REA393 |
| 同种亚型 | recombinant human IgG1 |
