Anti-HLA CLASS I BW6-FITC,human 30 tests
货号：
130-099-834 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-099-834 |
| 描述 | Clone REA143 recognizes HLA Bw6, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8-10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. Downregulation of HLA class I Bw6 allele has been reported in leukemic patients where it is suggested that via this downregulation, leukemic cells may circumvent attack by CTLs. Additional information: Clone REA143 displays negligible binding to Fc receptors. |
| 别名 | HLA-B, AS, SPDA1 |
| 克隆号 | REA143 |
| 同种亚型 | recombinant human IgG1 |
