Anti-GARP (LRRC32)-Biotin, human 30 test
货号：
130-104-362 基本售价：
询价 规格：
30 test
产品信息
概述| 货号 | 130-104-362 |
| 描述 | Clone REA166 recognizes the human glycoprotein A repetitions predominant (GARP) antigen, a 80 kDa type I membrane glycoprotein which belongs to the family of leucine rich repeat proteins. Expression of GARP protein is found on megakaryocytes, platelets, and activated regulatory T cells (Treg cells). GARP has been found to be associated with latency associated peptide (LAP), the prodomain responsible for conferring latency to non-active TGF-β. Thus, GARP as a latent TGF-β–binding protein (LTBP) regulates the surface expression of TGF-β and serves as a carrier of LAP, at the cell surface, to immune response active sites, where TGF-β is eventually activated and released to exert further physiological functions such as differentiation of regulatory T cells. Additional information: Clone REA166 displays negligible binding to Fc receptors. |
| 别名 | LRRC32, D11S833E, Glycoprotein A repetitions predominant (GARP), LRRC32 |
| 克隆号 | REA166 |
| 同种亚型 | recombinant human IgG1 |
