CD223-Biotin, human 30 tests
货号：
130-110-161 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-110-161 |
| 描述 | Clone REA351 recognizes the human CD223 antigen, a single-pass type I membrane protein also known as lymphocyte activation gene 3 protein (LAG-3). CD223 is a CD4 homolog with four extracellular Ig superfamily domains. Similar to CD4, CD223 oligomerizes at the surfaces of T cells and binds to MHC II on antigen presenting cells but with significantly higher affinity than CD4. CD223 is expressed on activated CD4+ and CD8+ T lymphocytes where it associates with the CD3–TCR complex at the cell surface and negatively regulates signal transduction. As a consequence, it negatively regulates T cell proliferation, function, and homeostasis. There is also increasing evidence of its involvement in regulatory function of tumor-infiltrated T cells in cancer, such as in Hodgkin’s lymphomas and in prostate cancer. CD223 is also expressed on activated NK cells, B cells, and plasmacytoid dendritic cells. Additional information: Clone REA351 displays negligible binding to Fc receptors. |
| 别名 | LAG-3, Protein FDC |
| 克隆号 | REA351 |
| 同种亚型 | recombinant human IgG1 |
