Anti-SLP-76-FITC, human 30 tests
货号：
130-107-085 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-107-085 |
| 描述 | Clone REA427 recognizes the human SH2 domain-containing leukocyte protein of 76 kDa (SLP-76) regardless of phosphorylation status. SLP-76 is a signal-transducing tyrosine phosphoprotein also known as lymphocyte cytosolic protein 2 (LCP2). It is involved in T cell antigen receptor–mediated signaling and is highly expressed in spleen, thymus, and peripheral blood leukocytes. The adapter molecule SLP-76 plays a central roles in T cell activation by recruiting enzymes and other adapters into multiprotein complexes that coordinate highly regulated signal transduction pathways. TCR stimulation facilitates phosphorylation of the TCRζ chains by the Src family kinase Lck, which allows for the recruitment and activation of the protein tyrosine kinase Zap-70. Phosphorylation of the essential adapter protein SLP-76 by Zap-70 creates docking sites for SH2 domain-containing adapter and effector proteins. The Grb2-related adapter, Gads, recruits the adapter SLP-76. SLP-76 recruits other signaling proteins, thereby inducing the assembly of multiprotein complexes. Additional information: Clone REA427 displays negligible binding to Fc receptors. |
| 别名 | LCP2, SLP76 |
| 克隆号 | REA427 |
| 同种亚型 | recombinant human IgG1 |
