Hu CD253 Pure RIK-1 100ug
货号：
550517 基本售价：
5035.0 元 规格：
100ug
产品信息
概述| 货号 | 550517 |
| 描述 | TRAIL (TNF-Related Apoptosis-Inducing Ligand), also known as Apo2L, is a member of the TNF ligand family. TRAIL is a type II membrane protein which may be expressed as a full-length, cell surface associated protein as well as in soluble form. Both surface and soluble forms of TRAIL rapidly induce apoptosis on a wide range of cell lines. TRAIL has been shown to cause apoptotic death in either tumorigenic or transformed cells, but not in normal cells. TRAIL-mediated apoptosis has been shown to involve the activation of caspases, and is blocked by over-expression of the caspase-1 protease inhibitor, CrmA. TRAIL has also been reported to induce the transcription factor NF- κ B in a cell type-specific manner. Two cognate TRAIL receptors DR4, and DR5, as well as two decoy receptors, DcR1/TRID and DcR2/TRUNDD have been identified. TRAIL has been shown to be involved in T cell cytoxicity, but the exact physiological role TRAIL plays in T-cell mediated cytotoxicity remains to be eluciated. This antibody recognizes human TRAIL. Human TRAIL cDNA was transferred to an expression vector and transfected into the 2PK-3 mouse B cell lympmoma cell line to generate stable transfectants, which were then used to immunize mice. This clone was selected based on its ability to block cytotoxic activity. TRAIL has been renamed as CD253 recently. |
| 别名 | TRAIL, APO-2L, TL2 |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
