Hu Cyclin E Pure HE67 100ug
货号：
554192 基本售价：
3484.0 元 规格：
100ug
产品信息
概述| 货号 | 554192 |
| 描述 | Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small proteins that bind to cyclins, cdks, or cyclin-cdk complexes, e.g., p21 and p27[Kip1]. Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (c-src, c-abl, SV40 large T-Ag), tumor suppressor genes (e.g., retinoblastoma protein [Rb] and p53), nucleolin, RNA polymerase II and others. Cyclin E is expressed in G1 and associates with cdk2 to form an active kinase. Cyclin E-cdk2 complexes play an important role in regulation of the G1/S restriction checkpoint in the cell cycle. Aberrant expression of cyclin E is associated with oncogenic transformation of cells. Cyclin E migrates at a reduced molecular weight of ~50 kDa. Clone HE67 recognizes human cyclin E. It does not cross-react with mouse cyclin E. Recombinant human cyclin E was used as immunogen. |
| 同种亚型 | IgG2b |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Recombinant human Cyclin E |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
