| 货号 | 2300S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IF-IC/F |
| 目标/特异性 | Aven Antibody detects endogenous levels of total Aven protein. |
| 使用方法 | WB(1:1000) F (1:200) IF-IC (1:50) |
| 供应商 | CST |
| 背景 | The Bcl-2 family regulates apoptosis in response to a wide range of stimuli through control of mitochondrial cytochrome c release and caspase activation (1-3). Cytosolic Apaf-1 forms a complex with caspase-9 in the presence of cytochrome c and dATP, ultimately leading to caspase-9 activation and subsequent activation of caspase-3. A large number of proteins have been found to interact with Bcl-2 and other family members that have been shown to help regulate apoptosis. Aven was identified in a yeast two-hybrid screen as a bcl-xL interacting protein (4). It also interacts with other anti-apoptotic family members, including Bcl-2, but fails to interact with pro-apopotic proteins Bax and Bak. Aven inhibits apoptosis and enhances anti-apopotic activity of Bcl-xL. It interferes with association with Apaf-1 and activation of caspase-9. Aven overexpression is associated with poor prognosis in acute lymphoblastic leukemia (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 50 |
Western blot analysis of extracts from HeLa (human), L929 (mouse) and PC12 (rat) cell lines, using Aven Antibody. | |
Western blot免疫印迹。用 Aven Antibody研究HeLa (人源)、L929 (小鼠源) 和 PC12 (大鼠源) 细胞系的细胞提取液。 |
