aIL-12 (REA121) (P35/P70)-PE-Vio770, h
货号：
130-103-677 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-103-677 |
| 描述 | Interleukin-12 (IL-12) is a 70–75 kDa heterodimeric cytokine composed of a 40 kDa heavy chain and a 35 kDa light chain. It is produced mainly by monocytes and macrophages as well as dendritic cells, primarily in response to stimulation with bacterial or viral antigens. IL-12 has also been described to be produced by non-hematopoietic cells such as keratinocytes and epidermoid carcinomas. IL-12 displays various effects on both NK and T cells, playing an essential role in the interaction between innate and adaptive immunity: It induces the production of IFN-γ alone or in synergy with IL-2, is a co-stimulator of both NK and T cell proliferation, and enhances cytolytic activity of both cell types. Moreover, IL-12 promotes the development of T helper 1 (Th1)-specific immune responses by promoting the differentiation of CD4+ cells towards a Th1 phenotype while inhibiting the production of Th2 cells. The antibody clone REA121 reacts with the p35 kDa chain and the p70 kDa heterodimer of human IL-12, but not with IL-12-p40. It recognizes the same epitope as clone B-T21.Additional information: Clone REA121 displays negligible binding to Fc receptors. |
| 别名 | IL12A, CLMF, IL-12A, NFSK, NKSF1, P35 |
| 克隆号 | REA121 |
| 同种亚型 | recombinant human IgG1 |
