Anti-IL-12R b2-PE-Vio770, m 200 tests
货号：
130-104-968 基本售价：
询价 规格：
200 tests
产品信息
概述| 货号 | 130-104-968 |
| 描述 | Clone REA200 recognizes the mouse Interleukin-12 receptor subunit beta-2 (IL-12R β2) antigen, a Single-pass type I membrane protein which forms the functional high affinity IL-12 receptor together with the IL-12R β1 subunit. While the IL-12R β1 subunit is constitutively expressed, the expression of the IL-12R β2 gene is up-regulated by interferon gamma. IL-12R β2 is expressed by Th1 cells and IL-12 signaling through the IL-12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL-12R β2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. The up-regulation of IL-12R β2 is found to be associated with a number of infectious diseases, such as Crohns disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Additional information: Clone REA200 displays negligible binding to Fc receptors. |
| 别名 | IL12RB2, IL-12RB2, Ifnm |
| 克隆号 | REA200 |
| 同种亚型 | recombinant human IgG1 |
