Anti-Oct3/4-PE, human, mouse 30 tests
货号：
130-109-763 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-109-763 |
| 描述 | Clone REA622 recognizes the human and mouse octamer-binding transcription factor 3/4 (Oct3/4). Oct3/4 is a homeodomain transcription factor belonging to the POU transcription factor family and is also known as POU domain class 5 transcription factor 1 (POU5F1). Oct3/4 is critical for the maintenance of totipotency in primate blastomeres and for pluripotency of the inner cell mass of developing mammalian embryos. This critical role of Oct3/4 is maintained in embryonic stem cells, the developing germline, and germline tumors, such as seminomas and embryonic teratocarcinomas. When inducing pluripotency in differentiated cells, Oct3/4 appears to be an essential but not the only required transcription factor. Oct3/4 acts as a transcriptional activator of genes involved in maintenance of undifferentiated state and as a repressor of differentiation-specific genes.Additional information: Clone REA622 displays negligible binding to Fc receptors. |
| 别名 | Oct3/4A, Oct-3A, Oct-4, OTF-3, OTF-4, POU5F1, NF-A3, MGC22487 |
| 克隆号 | REA622 |
| 同种亚型 | recombinant human IgG1 |
