Anti-FOXP3-PE, human & mouse 30 tests
货号：
130-098-119 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-098-119 |
| 描述 | The Anti-FoxP3 antibody specifically recognizes the forkhead/winged-helix transcriptional regulator FoxP3, also known as forkhead box P3, scurfin, and JM2. FoxP3 is expressed predominantly in regulatory T cells (Tregs) and is a major marker and functional regulator of Treg cell development and function.1,2 Mutations in the FoxP3 gene are linked to the autoimmune manifestations observed in the Scurfy mouse and humans with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.3,4 Studies in mice have shown that FoxP3-deficient animals lack Treg cells, whereas overexpression of the FoxP3 protein leads to profound immune suppression. |
| 别名 | AIID, DIETER, IPEX, JM2, PIDX, XPID |
| 克隆号 | 3G3 |
| 同种亚型 | mouse IgG1κ |
