Anti-Bcl-6-PE, human & mouse 30 tests
货号：
130-105-486 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-105-486 |
| 描述 | Clone REA373 recognizes the human and mouse Bcl-6 antigen, a member of the BTB-zinc finger family of proteins. Bcl-6 is a transcriptional repressor, expressed in germinal center T and B cells and in primary immature dendritic cells. It plays critical functions in various cell types within the adaptive and innate compartments of the immune system. Bcl-6 is highly up-regulated in B cells after T cell–dependent antigenic challenge, and is required for formation of germinal centers within which B cells undergo immunoglobulin affinity maturation. It also plays an important role in macrophages, where it mediates a dampening effect on inflammatory signaling through repression of chemokine expression and NF-κB target genes. Additional information: Clone REA373 displays negligible binding to Fc receptors. |
| 别名 | BCL6, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51 |
| 克隆号 | REA373 |
| 同种亚型 | recombinant human IgG1 |
