| 货号 | 3373/10 |
| 别名 | Cyclo(D-α-hydroxyisovaleryl-D-valyl- |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1111.32 |
| 分子式 | C54H90N6O18< |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Rose and Jenkins (2007) The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes. Bioelectrochem. 70387. Abdalahet al (2006) Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci.Letts. 40568. Davidson and Berman (1985) Interaction of valinomycin and monovalent cations with the (Ca2+,Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum. J.Biol.Chem. 260 7325. PMID: 3158656. |