| 货号 | 3516/10 |
| 别名 | Tunicamycin from Streptomycessp. |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Antibiotic; inhibits GlcNAc phosphotransferase (GPT). Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Activity induces ER stress and causes G1 arrest; can be used to induce autophagy. Tunicamycin contains four main components as follows:
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| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 844.95 |
| 分子式 | C39H64N4O16< |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Laueret al (2009) Primary murine airway smooth muscle cells exposed to poly(I:C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix. J.Biol.Chem. 284 5299. PMID: 19088077. Duriezet al (2008) The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated pathway. J.Biol.Chem. 283 32352. PMID: 18805786. Dinget al (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 282 4702. PMID: 17135238. |