| 货号 | 1759/100 |
| 别名 | 5,5-Dimethyl-3-[4-nitro-3-(trifluor |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Non-steroidal and silent antiandrogen. Binds to androgen receptors and also inhibits androgen biosynthesis in vitro. In rats in vivo it inhibits androgen-induced prostate weight increase and inhibits negative androgen-dependent gonadotropin feedback leading to an increase in luteinising hormone and testosterone. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 317.22 |
| 分子式 | C12H10F3N3 |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO |
| 参考文献 | Ayub and Levell (1987) Inhibition of rat testicular 17-α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro. J.Steroid Biochem. 28 43. PMID: 2956461. Raynaudet al (1985) Pharmacology and clinical studies with RU 23908 (Anandron). Prog.Clin.Biol.Res. 185A 99. PMID: 4034583. Raynaudet al (1984) The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer. The Prostate 5 299. PMID: 6374639. Raynaudet al (1979) Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues. J.Steroid Biochem. 11 93. PMID: 385986. |