| 货号 | 1611/50 |
| 别名 | 6-(2,3-Dichlorophenyl)-1,2,4-triazi |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na+ channels. Water-soluble salt available (lamotrigine isethionate, Cat. No. 2289). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 256.09 |
| 分子式 | C9H7Cl2N5 |
| 可溶性/溶解性 | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| 参考文献 | Zhenget al (2010) The anticonvulsive drug lamotrigine blocks neuronal α4β2 nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 335 401. PMID: 20688974. Grunzeet al (1998) Modulation of calcium and potassium currents by lamotrigine. Neuropsychobiology 38 131. PMID: 9778600. Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522. PMID: 9184596. Leachet al (1991) Neurochemical and behavioral aspects of lamotrigine. Epilepsia 32 S4. PMID: 1685439. |