| 货号 | 2555/10 |
| 别名 | 1-(4-Aminophenyl)-3-methylcarbamyl- |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 388.85 |
| 分子式 | C19H20N4O3 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Perraiset al (2009) Antagonism of recombinant and native GluK3-containing kainate receptors. Neuropharmacology 56 131. PMID: 18761361. Szabadoset al (2001) Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res.Bull. 55 387. PMID: 11489346. Paternainet al (1995) Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 14 185. PMID: 7826635. |