| 货号 | 3357/10 |
| 别名 | 5,11-Dimethyl-6H-pyrido[4,3-b]carba |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Naturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 246.31 |
| 分子式 | C17H14N2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Ohashiet al (1995) Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn.J.Cancer Res. 86 819. PMID: 7591958. Teweyet al (1984) Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J.Biol.Chem. 259 9182. PMID: 6086625. |