| 货号 | 5520/1 |
| 别名 | N-(2-Quinoxalinylcarbonyl)-O-[N-(2- |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 1101.26 |
| 分子式 | C51H64N12O12 |
| 可溶性/溶解性 | Soluble to 5 mM in DMSO |
| 参考文献 | Kwonet al (2011) Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression. J.Cell.Biochem. 112 3582. PMID: 21793044. Wanget al (2011) Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8 399. PMID: 21474104. Konget al (2005) Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 65 9047. PMID: 16204079. |