| 货号 | 0996/50 |
| 别名 | 4-(5H-Dibenzo[a,d]cyclohepten-5-yli |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Non-selective 5HT2 antagonist, migraine prophylactic. Also SETD7/9 inhibitor (IC50 = 1μM). Decreases expression and increases degradation of estrogen receptor (ER) α in breast tumor MCF7 cells. Inhibits growth of MCF7 xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 323.86 |
| 分子式 | C21H21N.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Takemotoet al (2016) Identification of cyproheptadine as an inhibitor of SET domain containing lysine methyltransferase 7/9 (Set7/9) that regulates estrogen-dependent transcription. J.Med.Chem. 59 3650. PMID: 27088648. Hoyeret al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157. PMID: 7938165. Moranet al (1994) Inhibitory 5-hydroxytryptamine receptors involved in pressor effects obtained by stimulation of sympathetic outflow from spinal cord in pithed rats. Br.J.Pharmacol. 113 1358. PMID: 7889292. |