| 货号 | 2656/10U |
| 别名 | (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Specific inhibitor of V-type (vacuolar) H+-ATPase that displays > 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >90 % |
| 计算分子量 | 866.09 |
| 分子式 | C46H75NO14 |
| 可溶性/溶解性 | Soluble in DMSO |
| 参考文献 | Honget al (2006) Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. J.Pharmacol.Exp.Ther. 319 672. PMID: 16895977. Nishiharaet al (1995) Specific inhibitors of vacuolar type H+-ATPases induce apoptotic cell death. Biochem.Biophy.Res.Comm. 212255. Muroiet al (1993) Folimycin (Concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitus virus before arrival to the golgi apparatus. Cell Struct.Function. 18139. |