| 货号 | 2607/50 |
| 别名 | 4-[[(1R)-2-[[(2R)-3-(1H-indol-3-yl) |
| 供应商 | Tocris |
| 生物活性 | Potent and selective CCK2 (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK1 receptors (IC50 values are 1.7 and 2717 nM for CCK2 and CCK1 respectively). Has negligible affinity at a range of other binding sites (IC50 > 10 μM). Exhibits anxiolytic activity following oral administration. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 614.73 |
| 分子式 | C35H42N4O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 130332-27-3 |
| 参考文献 | Andreet al (2005) Involvement of cholecystokininergic systems in anxiety-induced hyperalgesia in male rats: behavioral and biochemical studies. J.Neurosci. 25 7896. PMID: 16135746. Moodyet al (2001) CI-988 inhibits growth of small cell lung cancer cells. J.Pharmacol.Exp.Ther. 299 1154. PMID: 11714907. Hugheset al (1990) Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc.Natl.Acad.Sci.USA 876728. |