PF 06465469 (50 MG)
货号：
4710/50 基本售价：
16140.8 元 规格：
50 mg
产品信息
概述| 货号 | 4710/50 |
| 别名 | (R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of interleukin-2 inducible T cell kinase (ITK) (IC50 = 2 nM). Also exhibits inhibitory activity against Bruton's tyrosine kinase (BTK) (IC50 = 2 nM). Displays nanomolar potencies in a cell-based IP1 assay and human whole blood assay (IC50 values are 31 and 48 nM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >95 % |
| 计算分子量 | 523.63 |
| 分子式 | C30H33N7O2 |
| 可溶性/溶解性 | Soluble to 5 mM in DMSO with gentle warming |
| 参考文献 | Zapfet al (2012) Covalent inhibitors of interleukin-2 inducible T cell kinase (Itk) with nanomolar potency in a whole-blood assay. J.Med.Chem. 55 10047. PMID: 23098091. |
