| 货号 | 4273/50 |
| 别名 | 5,11-Dihydro-2-[[2-methoxy-4-[[4-(4 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). Inhibits both G2019S mutant and wild-type LRRK2 kinase activity (IC50 values are 6 and 13 nM respectively). Causes dephosphorylation, ubiquitination and degradation of LRRK2. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 570.09 |
| 分子式 | C31H38N8O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Zhaoet al (2015) LRRK2 Dephosphorylation increases its ubiquitination. Biochem.J. 469 107. PMID: 25939886. Denget al (2011) Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat.Chem.Biol. 7 203. PMID: 21378983. |