GSK 1562590 hydrochloride (50 MG)
货号：
5110/50 基本售价：
15545.9 元 规格：
50 mg
产品信息
概述| 货号 | 5110/50 |
| 别名 | N-[(1R)-1-[3'-(Aminocarbonyl)[1,1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-4H-1,4-benzoxazine-4-acetamide hydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | High affinity and selective urotensin II (UT) receptor antagonist (pKi values are 9.14, 9.28, 9.34, 9.64 and 9.66 at monkey, human, mouse, cat and rat recombinant receptors respectively). Exhibits selectivity for UT receptors over a range of GPCRs, ion channels, enzymes and neurotransmitter transporters. Supresses human urotensin-II (hU-II)-induced contraction of isolated rat aorta in vitroandex vivo. Inhibits the hU-II-induced increase in mean blood pressure in vivo. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 617.95 |
| 分子式 | C30H30Cl2N4< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Behmet al (2010) GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo. Br.J.Pharmacol. 161 207. PMID: 20718751. |
