| 货号 | 2332/50 |
| 别名 | (R)-(+)-N-Cyclopropylmethyl-α-ethyl- |
| 供应商 | Tocris |
| 生物活性 | Selectiveσ1 receptor ligand (KD = 19.1 nM), with little or no activity at σ2 receptors (IC50 > 1000 nM). Inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC50 value is approximately 100 nM). Weak inhibitor of brain 5-HT uptake in vitro. Exhibits neuroprotective and antidepressant effects. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 355.94 |
| 分子式 | C23H29N.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Akunneet al (2001) Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant. Neuropharmacology 41 138. PMID: 11445194. O'Neillet al (1995) The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia. Eur.J.Pharmacol. 283 217. PMID: 7498313. |