| 货号 | 14749-500ug |
| 描述 | Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively).1,2 It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B.1,3 Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation.4 On a related note, fostriecin was first identified as an antitumor antibiotic.5 |
| 别名 | Antibiotic CI-920;Phosphotrienin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Walsh, A.H.,Cheng, A. and Honkanen, R.E. Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Letters 416(3), 230-234 (1997). 2.Hastie, C.J. and Cohen, P.T. Purification of protein phosphatase 4 catalytic subunit: Inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Letters 431(3), 357-361 (1998). 3.McCluskey, A.,Sim, A.T.R. and Sakoff, J.A. Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies. Journal of Medicinal Chemistry 45(6), 1151-1175 (2002). 4.Zheng, Y.G.,Wu, J.,Chen, Z., et al. Chemical regulation of epigenetic modifications: Opportunities for new cancer therapy. Medicinal Research Reviews 28(5), 645-687 (2008). 5.Tunac, J.B.,Graham, B.D. and Dobson, W.E. Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties. J.Antibiot.(Tokyo) 36(12), 1595-1600 (1983). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 452.4 |
| 分子式 | C19H26O9P • Na |
| CAS号 | 87810-56-8 |
| 稳定性 | ≥ 2 years |
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