| 货号 | 4173/50 |
| 别名 | (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM). Exhibits > 80-fold selectivity for 5-HT2A over other serotonergic receptor subtypes. Antipsychotic agent in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 373.46 |
| 分子式 | C22H28FNO3 |
| 可溶性/溶解性 | Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO |
| 参考文献 | Ardayfioet al (2008) The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. J.Pharmacol.Exp.Ther. 327 891. PMID: 18772320. Kehneet al (1996) Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. J.Pharmacol. 277 968. PMID: 8627580. Sorensenet al (1993) Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J.Pharmacol.Exp.Ther. 266 684. PMID: 8102646. |