| 货号 | 4062/50 |
| 别名 | (2S)-2-Amino-2-[(1S,2S)-2-carboxycy |
| 供应商 | Tocris |
| 生物活性 | Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 (Cat. No. 1209). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 397.33 |
| 分子式 | C20H17NNa2O5 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 参考文献 | Johnsonet al (1999) [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology 38 1519. PMID: 10530814. Fitzjohnet al (1998) The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology 37 1445. PMID: 9886667. Ornsteinet al (1998) 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability. J.Med.Chem. 41 358. PMID: 9464367. |