| 货号 | 4018/50 |
| 别名 | (2E)-N-(1-Acetyl-2,3-dihydro-1H-ind |
| 供应商 | Tocris |
| 生物活性 | Selective NPY Y2 antagonist (IC50 = 0.1 μM). Displays 100-fold selectivity over NPY Y1, Y4 and Y5 receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 510.67 |
| 分子式 | C32H38N4O2 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming |
| 参考文献 | Bonaventureet al (2004) Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. J.Pharmacol.Exp.Ther. 308 1130. PMID: 14617685. Jablonowskiet al (2004) Novel non-peptide neuropeptide Y Y2 receptor antagonists. Bioorg.Med.Chem.Lett. 14 1239. PMID: 14980673. |