| 货号 | 3706/50 |
| 别名 | 5-(2-Phenyl-pyrazolo[1,5-a]pyridin- |
| 供应商 | Tocris |
| 生物活性 | Selective ERK inhibitor (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α(IC50 = 10 μM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα at concentrations less than 30 μM. Also inhibits TGFβ-induced AP-1 activation in Mv1Lu cells (IC50 = 3.1 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 327.34 |
| 分子式 | C18H13N7 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 865362-74-9 |
| 参考文献 | Perrettet al (2013) Signaling to Extracellular Signal-regulated Kinase from ErbB1 Kinase and Protein Kinase C. J Biol Chem. 19 288. PMID: 23754287. Ohoriet al (2005) Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem.Biophys.Res.Comm. 336 357. PMID: 16139248. |