(R)-DRF053 dihydrochloride (50 MG)
货号：
3610/50 基本售价：
14653.6 元 规格：
50 mg
产品信息
概述| 货号 | 3610/50 |
| 别名 | 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanoldihydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3 αβ(IC50= 4.1 μM). Also shown to inhibit amyloid-β production in N2A-APP695cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 490.43 |
| 分子式 | C23H27N7O.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 1056016-06-8 |
| 参考文献 | Oumataet al (2008) Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J.Med.Chem. 51522. |
