TCS 21311 (50 MG)
货号：
4221/50 基本售价：
14356.2 元 规格：
50 mg
产品信息
概述| 货号 | 4221/50 |
| 别名 | 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
性能| 供应商 | Tocris |
| 生物活性 | Potent JAK3 inhibitor (IC50 = 8 nM). Selective for JAK3 over JAK1, JAK2 and TYK2 (IC50 values are 1017, 2550 and 8055 nM respectively). Also inhibits GSK-3β, PKCα and PKCθ(IC50 values are 3, 13 and 68 nM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 526.51 |
| 分子式 | C27H25F3N4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Thomaet al (2010) Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family. J.Med.Chem. 54284. |
