| 货号 | 2650/50 |
| 别名 | 5-[2-[4-[2-(Dimethylamino)ethoxy]ph |
| 供应商 | Tocris |
| 生物活性 | Potent B-Raf inhibitor (Kd = 0.3 nM). Selective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively). Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 453.54 |
| 分子式 | C27H27N5O2 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Kinget al (2006) Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res. 66 11100. PMID: 17145850. Takleet al (2006) The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg.Med.Chem.Lett. 16 378. PMID: 16260133. |