| 货号 | 3129/50 |
| 别名 | 2-[(Isopropylaminocarbonyl)amino]-N |
| 供应商 | Tocris |
| 生物活性 | High affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 593.66 |
| 分子式 | C28H34F3N5O4S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 445479-97-0 |
| 参考文献 | Youet al (2010) CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels. Mol.Pharmacol. 77 211. PMID: 19864434. Cherneyet al (2008) Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J.Med.Chem. 51 721. PMID: 18232650. |