MLN2480
货号：
19675-25mg 基本售价：
13832.0 元 规格：
25 mg
产品信息
概述| 货号 | 19675-25mg |
| 描述 | MLN2480 is an orally bioavailable pan-Raf kinase inhibitor that inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models.1 It shows antitumor activity in melanoma, colon, lung, and pancreatic cancer xenograft models.2 MLN2480 demonstrates synergistic activity with TAK-733, an allosteric MEK kinase inhibitor.3 |
| 别名 | BIIB-024;TAK-580; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Whittaker, S.R.,Cowley, G.S.,Wagner, S., et al. Combined pan-RAF and MEK inhibition overcomes multiple resistance mechanisms to selective RAF inhibitors. Molecular Cancer Therapeutics 14(12), 2700-2711 (2015).
2.Rasco, D.W.,Olszanski, A.J.,Patnaik, A., et al. MLN2480, an investigational oral pan-RAF kinase inhibitor, in patients (pts) with relapsed or refractory solid tumors: Phase I study. Journal of Clinical Oncology 31(suppl 15), (2013).
3.Cunniff, E.G.C.,Zhang, J.,Chouitar, J., et al. Use of combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 on the growth of BRAF-mutant and RAS-mutant preclinical models of melanoma and CRC. Journal of Clinical Oncology 31(15 Suppl), (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 506.3 |
| 分子式 | C17H12Cl2F3N7O2S |
| CAS号 | 1096708-71-2 |
| 稳定性 | ≥ 2 years |
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