| 货号 | 4527/50 |
| 别名 | N-[[(4R)-5,5-Dimethyl-3-(phenylsulf |
| 供应商 | Tocris |
| 生物活性 | Potentα2β1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). Displays selectivity for α2β1overαvβ3,α5β1,α6β1andαIIbβ3 at concentrations exceeding 1000 nM. Reduces collagen IV production in mesangial cells. Active in vivo; prevents ferric chloride-induced clot formation in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 520.62 |
| 分子式 | C23H28N4O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in 1.1eq. NaOH |
| 参考文献 | Borzaet al (2012) Inhibition of integrin α2β1 ameliorates glomerular injury. J.Am.Soc.Nephrol. 23 1027. PMID: 22440900. Milleret al (2009) Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proc.Natl.Acad.Sci.U.S.A. 106 719. PMID: 19141632. |