| 货号 | 4730/50 |
| 别名 | 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2 |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 372.42 |
| 分子式 | C22H20N4O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Noronhaet al (2008) Inhibitors of ABL and the ABL-T315I mutation. Curr.Top.Med.Chem. 8 905. PMID: 18673174. Zhouet al (2007) Crystal structure of the T315I mutant of AbI kinase. Chem.Biol.Drug.Des. 70 171. PMID: 17718712. |